Is Shrimp a Smart Choice or Something to Avoid With Stomach Ulcers?

1Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, Via de Sanctis s. n. c, 86100 Campobasso, ItalyFind articles by.

Infection with Helicobacter pylori is a critical cause of gastrointestinal diseases. A crucial host response associated with H. pylori infection causes inflammation in the stomach, which is marked by the steady migration of T-helper (Th) cells to the infection site and the production of specific cytokines. Adequate nutritional status, especially frequent consumption of dietary antioxidants, appears to protect against infection with H. pylori. The point of this study was to find out if astaxanthin (AXT) from the cephalothorax of a shrimp could change the release of cytokines by splenocytes in H pylori-infected mice (n = 60). Female mice aged six to eight weeks were split into three groups, with twenty mice in each. For six weeks, each group was given 10 mg or 40 mg of AXT by mouth every day. After six weeks, a trend toward interferon gamma (IFN-γ) upregulation was found (40 mg; p < 0. 05) and a significant dose-dependent increase of interleukin 2 (IL-2) and IL-10 (both p < 0. 05) was observed. These findings suggest that AXT causes more IL-2 to be made and a change to a balanced Th1/Th2 response by raising IFN-γ and IL-10 levels. We concluded that AXT may influence the pattern of cytokines during H. pylori infection.

Helicobacter pylori is a gram-negative bacterium that infects more than half of the world’s population [1]. H. colonization by H. pylori usually starts in childhood and lasts a person’s whole life, leading to chronic gastritis, peptic ulceration, gastric adenocarcinoma, and primary gastric lymphoma [2]. Long-term gastric inflammation is the hallmark of chronic H. pylori infection and is thought to underlie several gastrointestinal diseases. The severity of gastric inflammation varies, depending on the host immune response against this bacterium. However, colonization by H. pylori recruits host immune system cells such as macrophages, neutrophils, and lymphocytes to the gastric mucosa [3,4]. Although T-helper 1 (Th1) cell responses are the main cause of inflammation in the gastric mucosa, it is known that H pylori infection also induces the differentiation of anti-inflammatory T-helper 2 (Th2) cells [5,6]. Th1 and Th2 subsets release cytokines in different ways. The Th1 phenotype is marked by a high level of interferon gamma (IFN-γ), which helps inflammation last longer and stops the Th2 response from happening, which could be helpful. In particular, higher levels of IFN-γ create a microenvironment that is dominated by Th1, which stops the activity of interleukin 2 (IL-2), which is an important part of starting Th2 responses and protecting against infection [7,8]. However, there is evidence that switching from a Th1-polarized state to a mixed Th1/Th2 response, which is marked by the production of IL-10, may help get rid of the H pylori [9,10]. People are interested in dietary antioxidants because they can change the immune system. Specifically, they can slow down Th1-type activation pathways and cause both Th1 and Th2 cytokines to be released at the same time [11,12]. Observational studies have also found a link between not getting enough antioxidants in your food and a higher risk of H pylori acquisition [13,14]. Astaxanthin (AXT) is a xanthophyll carotenoid that possesses antioxidant, anti-inflammatory, and immune-enhancing properties. This chemical is found all over nature. It is mostly made by microalgae and phytoplankton. It is a reddish-orange color that many crustaceans, like shrimp, crabs, and lobster, use in the ocean [15]. Several lab tests have shown that AXT from the microalga Haematococcus pluvialis may lower the number of bacteria that are linked to H pylori infection as well as inhibit colonization and inflammation. Additionally, it was observed that AXT extracted from H. pluvialis induced a shift from a Th1-dominant state to a balanced Th1/Th2 response [16,17]. AXT is easy to find in shrimp shells, especially in the cephalothorax and when fish oil is used to extract it [18]. However, there isn’t enough information on how AXT from this source affects the immune system during H pylori infection. We looked at what happened when different amounts of AXT from the cephalothorax of shrimp were taken by mouth and how that affected the release of cytokines by splenocytes in H pylori-infected mice.

The saponification of AXT esters is a well-known hydrolysis treatment method after AXT extraction. shows the separation of fractions. Free AXT was identified according to the retention time of an AXT standard. The high-performance liquid chromatography (HPLC) test showed that fractions with a retention time of 10 to 20 minutes disappeared after being broken down. When compared to before hydrolysis, the AXT fraction, which had a retention time of 4 minutes, grew a lot after hydrolysis. These results indicate that saponification treatment hydrolyzes AXT esters.

Stomach ulcers, also known as peptic ulcers, are painful sores in the lining of the stomach. They can cause abdominal discomfort, nausea, and fatigue. Making wise diet choices is crucial for managing symptoms and promoting healing. But what about shrimp – is it a good option or something to avoid when you have stomach ulcers? Let’s take a thorough look at the potential pros and cons.

First, a quick overview of ulcers They occur when the protective mucus layer in the stomach erodes, allowing digestive juices to damage the tissue underneath Common causes include

Infection with Helicobacter pylori (H. pylori) bacteria
Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs)
Excess stomach acid production
Smoking, stress, or genetic factors

Ulcers can develop in the stomach itself or upper part of the small intestine. Symptoms include burning abdominal pain, bloating, nausea, and fatigue.

Now, what are the potential benefits of eating shrimp with an ulcer?

Provides High-Quality, Gentle Protein

Shrimp supply excellent bioavailable protein to aid healing without overworking the stomach like fatty meats might.

Contains Anti-Inflammatory Omega-3s

Shrimp have omega-3s like EPA and DHA that reduce inflammation implicated in ulcers.

Has a Low Acidity pH

The pH of shrimp is close to neutral, meaning it’s low acidity and less likely to further irritate the damaged stomach lining.

Provides the Mineral Zinc

Zinc supports immune health and wound healing. Shrimp provide it in a highly bioavailable form.

Contains Choline

This nutrient assists with fat metabolism and may help protect the stomach lining. Shrimp are a top source.

In moderation, shrimp offer protective nutrients while being gentle on the sensitive stomach.

However, there are also some potential issues with shrimp to consider:

Shrimp naturally contain a lot of sodium, which can stimulate acid production and worsen symptoms.
Some individuals are allergic to shellfish, including shrimp, which could be dangerous.
Shrimp have high dietary cholesterol, which some doctors advise limiting.
Frying or breading shrimp adds fat, making it harder to digest.

Those with severe ulcers likely still need to limit shrimp intake and pay attention to preparation methods.

Here are suggestions for safely including shrimp in an ulcer diet:

Eat shrimp in moderation as part of a balanced, bland, low-fat diet. Limit to 2-3 oz portions just a couple times weekly.
Choose wild-caught over farmed shrimp for more anti-inflammatory omega-3 fats.
Opt for low-sodium options or rinse precooked shrimp to reduce excess salt.
Stick to healthy cooking techniques like grilling, steaming, or baking without added oils or butter.
Pair shrimp with other ulcer-friendly foods like leafy greens, carrots, yams, oatmeal and brown rice.
Stay well hydrated and restrict other high sodium foods to counterbalance the salt in shrimp.
Take a probiotic to potentially combat H. pylori infection.
Avoid shrimp entirely if you have a known shellfish allergy or experience discomfort after eating it.

Here are some balanced meal ideas featuring shrimp:

Grilled shrimp over greens with avocado, tomatoes, balsamic vinegar, and cooked quinoa.
Sheet pan dinner with shrimp, roasted Brussels sprouts and butternut squash.
Shirataki noodle pad thai with shrimp, carrots, cabbage, cilantro and ginger soy sauce.
Green salad topped with boiled shrimp, blueberries, walnuts, and raspberry vinaigrette.
Burrito bowl with cilantro lime shrimp, brown rice, black beans, peppers, onions and avocado.

The key is choosing healthy preparations and pairing shrimp with ample antioxidant-rich plant foods to benefit your stomach. Work with your healthcare provider to optimize nutrition while soothing your individual ulcer symptoms.

The Bottom Line: Can Shrimp Fit Into an Ulcer-Friendly Diet?

In moderation, shrimp can be a safe addition to the diet for many with ulcers thanks to its protein, gentle nature, and nutrients. However, those with severe cases may need to avoid it entirely. Pay attention to personal tolerance, opt for low sodium, and balance with ulcer-friendly foods. With guidance from your doctor, shrimp can be one part of an overall diet focused on healing ulcers by reducing inflammation and protecting the stomach lining.

is shrimp good for stomach ulcers

4. Effect of AXT on IL-2 Release in Splenocytes of H. pylori-Inoculated Mice

To extend the above findings that AXT played a key role in mediating H. pylori-associated inflammation, we next measured the release amount of IL-2 in splenocytes of H. pylori-inoculated mice supplemented with 10 and 40 mg of AXT ( ). Although no statistical significance was observed, the synthesis of IL-2 was increased in splenocytes of H. pylori-inoculated mice treated with 10 mg of AXT. However, after six weeks, the level of IL-2 was significantly greater (p < 0. 05) in animals given 40 mg of AXT compared to mice given 10 mg of AXT or animals that were not given any medicine.

In the past few years, eating foods that contain phytochemicals has been linked to better health and avoiding getting sick [19,20,21,22,23]. Recently, AXT has been extensively studied due to its numerous interesting biological activities, including anti-microbial and anti-infection activities. There is evidence from both lab and real-life models that AXT can change the immune response, which is very important for fighting infectious diseases [24,25,26]. However, there is very little information on the immunomodulatory effects of AXT extracted from shrimps. Noteworthy, shrimp waste generated by shrimp processing industries is one of the cheapest raw materials to recover AXT. For a number of infection diseases, immunostimulatory compounds are needed to stop bacteria from growing and get rid of the infection. This study suggests that AXT controls the production of IFN-γ, IL-10, and IL-2 in the spleenocytes of H pylori-infected BALB/c mice. It was shown that splenocytes from mice that got the higher dose of AXT made more IFN-γ, IL-10, and IL-2 than splenocytes from control mice. These data are consistent with a previous study showing that H. The pylori virus causes a Th1 response and the release of IFN-γ. AXT treatment changed this to a Th2 response and the release of IL-4 [17]. Liu and Lee showed that a dietary cell extract from the microalgae Chlorococcum sp. , which includes AXT, reduced the bacterial load and modulated cytokine production in H. pylori-infected BALB/c mice. These changes were linked to a change in the T-lymphocyte response from a Th1 response dominated by IFN-γ to a Th1/Th2 response dominated by IFN-γ and IL-4 [27]. A study in H. researchers looked at gastric inflammatory markers and ILs (IL-4, IL-6, IL-8, IL-10, and IFN-γ) in H. pylori-positive patients with functional dyspepsia after they were treated with AXT from H. pluvialis. There was a significant upregulation of CD4 and downregulation of CD8 in patients with H. pylori treated with AXT. However, cytokine levels in the infected tissues were not affected by AXT treatment [28]. We are aware that our study has some flaws, mainly the fact that we didn’t look at any stomach tissue samples. However, this study’s results suggest that giving AXT from the cephalothorax of a shrimp may change the profile of cytokines during H pylori infection. Studies should be done on humans to see if AXT from the same source changes the levels of inflammatory chemicals in H pylori-infected tissues.

4. Infection of Mice

Sixty mice were inoculated with 108 colony forming units (CFU) of the H. pylori J99 strain three times at two-day intervals. A positive control group was comprised by mice which were infected with H. pylori, but neither treated nor handled in any way. All mice were daily attended twice by a veterinarian to ensure the animals’ welfare during the experiment.

Top 10 Foods to Heal Your Stomach Ulcer Naturally

FAQ

Can you eat seafood with an ulcer?

Fatty fish like salmon, mackerel, and sardines provide omega-3 fats, which can reduce inflammation and may be helpful in preventing another ulcer. Fermented dairy: Products like kefir and Greek yogurt provide probiotics (helpful bacteria) along with protein, so they’re good choices.

Can I have shrimp with gastritis?

You can partake in foods such as: Shellfish and seafood (not fried) Eggs and egg products (not fried)

Is shrimp good for your gut?

Prebiotics and Probiotics: Certain types of seafood, such as shrimp and crab, contain prebiotic fibers that nourish the beneficial bacteria in the gut.

What food calms a stomach ulcer?

Best: Fiber-Rich Foods Apples, pears, oatmeal, and other foods that are high in fiber are good for ulcers in two ways. Fiber can lower the amount of acid in your stomach while easing bloating and pain. Research has also shown that a diet rich in fiber may help prevent ulcers.

Can turmeric help a stomach ulcer?

Turmeric is currently being studied as a potential treatment for ulcers as well. Garlic, decaffeinated green tea, and licorice round out the list of things you might want to incorporate in your diet. If your stomach ulcer is being treated with an antibiotic, consider taking a probiotic supplement as part of your diet plan.

What foods can help heal a stomach ulcer?

Yogurt, miso, kimchi, sauerkraut, kombucha, and tempeh are examples of foods high in probiotics. They could assist in treating ulcers by preventing Helicobacter pylori infection or enhancing the efficacy of current therapies.

Can you eat spicy food on an ulcer diet?

Herbs and spices: Hot, spicy foods are usually avoided on an ulcer diet, but a review of studies on food and H.pylori found that some spices added for flavor also help kill the bacteria. You can freely use most mild herbs and spices because they’re sources of antioxidants.

Can an ulcer diet help a sore esophagus?

However, following an ulcer diet can help reduce the pain and irritation associated with these sores on the lining of the stomach, esophagus, or small intestine. Some foods, like berries and grapes, help repair damaged tissue. But alcohol and spicy foods, for example, irritate the digestive tract’s natural layer of protection and can worsen ulcers.